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Publish Date:  Dec 19, 2025

Milano, IT Bologna, IT

PMO Sr. Manager, Development Strategy & Operations

Purpose of the Job

The PMO Sr. Manager, Development Strategy & Operations acts as a strategic partner and operational right hand to the Chief Development Officer (CDO), enabling the effective execution of priorities across the development organization. The role is responsible for orchestrating high-level initiatives, driving cross-functional alignment, managing strategic communications, and ensuring disciplined follow-through on key decisions. By providing structure, insight, and coordination, the role allows the CDO to focus on the most critical strategic and operational decisions. This position exists to strengthen execution at the intersection of science, business, and organizational performance.

Key Responsibilities

Strategic Execution & Business Planning

  • Translate CDO priorities into actionable execution plans with clear ownership, timelines, and accountability.

  • Coordinate the development of annual objectives, KPIs, and business plans for the development function.

  • Monitor progress of strategic initiatives and ensure alignment across development functions, including Clinical Development, Regulatory, Operations, Safety, and Biometrics.

Executive Decision Support

  • Prepare, integrate, and manage content for leadership team meetings, governance forums, town halls, and Board-level discussions.

  • Act as a thought partner and trusted sounding board to the CDO on both day-to-day matters and long-term strategic planning.

  • Synthesize complex scientific, operational, and business information into clear briefings, insights, and recommendations to support decision-making.

Cross-Functional Coordination

  • Serve as a central liaison across R&D leadership, functional heads, Finance, HR, and selected external stakeholders.

  • Ensure follow-up, execution, and accountability for key decisions and agreed action items.

  • Facilitate effective information flow, proactively identifying and removing bottlenecks impacting the CDO and the development organization.

Operations & Governance

  • Manage and continuously evolve development governance forums such as Portfolio Reviews, Risk Committees, and Leadership Team offsites.

  • Oversee coordination of budgets, organizational planning, and internal operations in close partnership with Finance, HR, and other support functions.

  • Drive continuous improvement initiatives to streamline processes, enhance productivity, and sharpen organizational focus.

Internal Communication & Culture

  • Develop and deliver clear, consistent communications that reflect CDO priorities and reinforce transparency across the development organization.

  • Support organizational health, engagement, and change initiatives, contributing to a high-performance and collaborative culture.

Qualifications

  • Minimum of 8 years of professional experience in biopharma, life sciences, management consulting, or strategy-focused roles.

  • Experience in, or close exposure to, drug development and/or clinical operations is highly advantageous.

  • Advanced degree preferred (PhD, MD, MBA, or equivalent), ideally with a scientific and/or business background.

  • Demonstrated ability to lead through influence within complex, matrixed organizations.

  • Strong organizational, analytical, communication, and problem-solving skills.

  • High level of discretion, emotional intelligence, and capability to manage sensitive and confidential information.

  • Proven experience partnering with senior executives and driving cross-functional, enterprise-level initiatives.

 

Company

Alfasigma is a global pharmaceutical company founded over 75 years ago in Italy, where it is headquartered (in Bologna and Milan). The Group operates in over 100 markets spanning Europe, North and South America, Asia, and Africa. It has offices in many countries, including Italy, the US, Spain, Germany, Mexico, and China; production sites in Italy (Pomezia, RM; Alanno, PE; Sermoneta, LT; Trezzano Rosa, MI), Spain (Tortosa, Baix Ebre), and the United States (Shreveport, Louisiana); and R&D labs in Italy (Pomezia and Bergamo). Alfasigma employs approximately 4,000 people dedicated to research, development, production, and distribution of medicinal products, contributing to its mission to provide better health and a better quality of life for patients, caregivers, and healthcare providers. It focuses on three main therapeutic areas: Gastroenterology, Vascular, and Rheumatology. Its portfolio spans from primary care to specialty care, rare disease medications, and consumer health products, including medical foods and nutraceuticals.

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